Analgesic drugs according to the WHO classification:
Level 1 drugs (non-morphine drugs)
Used in mild to moderate pain.
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Acetylsalicylic acid (Aspirin, part of NSAIDs)
Pregnant women are reminded that taking NSAIDs is strictly contraindicated during the third trimester of pregnancy.
- Nefopam (this molecule can also be classified as level 2 because it is indicated for moderate to severe pain, but it is not a opioid).
Level 2 drugs (contains weak opioids)
Used in moderate to severe pain.
- Nefopam (this molecule can also be classified as level 1 because it is not a opioid, but it is indicated for the treatment of moderate to severe pain).
- Dextropropoxyphene (no longer marketed in France, and is being phased out in Europe)
- There are also associations between level 1 drugs and level 2 drugs. Refer to the sheets for each treatment concerning maximum doses and adverse effects. Some combinations contain caffeine: it should be remembered that these drugs are particularly responsible for daily headaches through drug abuse in certain contexts.
Level 3 drugs (contains strong opioids)
Used in severe pain, especially in pain of cancerous origin.
- Morphine (rapid or prolonged release forms, injectable)
- Oxycodone (rapid or prolonged release forms, injectable)
-Fentanyl (patch, lollipops, glossettes, spray, injectables)
Medicines for neurological pain:
Laroxyl (amitriptyline), Anafranil (clomipramine), Effexor (venlafaxine), Cymbalta (duloxetine), Ixel (milnacipran)
Neurontin (Gabapentin), Lyrica (pregabalin), Trileptal (oxcarbazepine), Tegretol (carbamazepine)
Medicamentos para la migraña:
Currently the treatment of the crisis uses analgesics of level 1 in first intention (paracetamol, AINS) followed in the event of inefficiency of the catch of a triptan.
Background treatment :
Rye ergot derivatives:
Antibody blocking the CGRP protein responsible for pain in migraine. These therapies are revolutionizing the treatment of migraine.