Apart from indications for cardiac purposes, Metoprolol 200 LP is indicated in the long-term treatment of migraine.
- Asthma and chronic obstructive pulmonary disease, in their severe forms.
- Heart failure not controlled by treatment.
- Cardiogenic shock.
- Unpaired second and third degree atrioventricular blocks.
- Prinzmetal's angina (in pure forms and as monotherapy).
- Sinus disease (including sinoatrial block).
- Bradycardia (<45 to 50 beats per minute).
- Raynaud's phenomenon and peripheral arterial disorders, in their severe forms.
- Untreated pheochromocytoma.
- Hypersensitivity to metoprolol.
- History of anaphylactic reaction.
This medication is generally not recommended during breast-feeding.
- Very common: Asthenia.
- nausea, abdominal pain, diarrhea, constipation,
- bradycardia, severe if applicable, postural hypotension, palpitations,
- cold extremity,
- dyspnea on exertion.
- heart failure, drop in blood pressure, precordial pain, cardiogenic shock in patients with myocardial infarction,
- depression, concentration disturbance, drowsiness, insomnia, nightmare,
- increased weight.
- dry mouth,
- slowed atrioventricular conduction or worsening of existing atrioventricular block, arrhythmia,
- Raynaud's syndrome,
- worsening of existing intermittent claudication,
- nervousness, anxiety,
- visual defects, dryness or eye irritation, conjunctivitis,
- antinuclear antibodies exceptionally accompanied by clinical manifestations like lupus syndrome and leading to discontinuation of treatment.
- Very rare:
- retroperitoneal fibrosis,
- gangrene in patients with severe peripheral circulatory disorders,
- stroke, amnesia, memory impairment, confusion, hallucination,
- Peyronie's disease,
- Exacerbation of psoriasis,
- reaction photosensitivity,
Like all beta blockers, extreme bradycardia, hypotension, bronchospasm with respiratory failure, heart failure can occur justifying the use of dobutamine, glucagon or even an external pace maker, bronchodilator.