Deficiencies or overconsumption
Refsum’s disease
Autosomal recessive transmission disease. Linked to a deficiency in an enzyme allowing the degradation of phytanic acid and therefore linked to an accumulation of the latter. Etiology Refsum’s disease is caused by mutations in the
Acute forms of neuropathies. ABONNE
Installation in a few hours: Mainly vasculitis (polyarteritis nodosa) The picture is more of a multineuritis with multiple radicular or truncal involvement. Installation in a few days: – Guillain-Barrè syndrome and its variants. – Neuropathy
Multiple deficiency syndrome.
Painful polyneuropathy with ocular involvement and deafness. Seen in disadvantaged populations, especially in times of war. Linked to multiple deficiencies. Are associated with it: A painful distal polyneuropathy, Fatigue, irritability, sleep disturbances in the context
Alcoholic polyneuropathy. ABONNE
It is linked to direct toxicity of alcohol and its metabolites on the neurological tissue linked to vitamin malabsorption (competition between vit B1 and alcohol in the digestive tract, gastropancreatic disorders causing malabsorption of vitamins)
Vitamin E deficiency
Linked to pathologies of biliary excretion (biliary cirrhosis, fibrosis of the bile duct, Crohn’s disease, blind loop syndrome) or to a familial deficiency of the alpha-tocopherol receptor. He gives : Peripheral motor and sensory neuropathy
Thiamine deficiency (Vitamin B1) or Beriberi
The manifestations of thiamine deficiency are: Polyneuropathy (affecting several nerves) distal and symmetrical with cramps, burns, dysesthesia, balance disorders (ataxia). Global cardiac involvement with high output heart failure, pulmonary and peripheral edema. Encephalopathy (Gayet-Wernicke). These
Pyridoxine deficiency (Vitamin B6).
This deficiency is rare, vitamin B6 being very widespread in the diet. Note that 3 drugs antagonize it: isoniazid, penicillamine and hydralazine. Clinical signs : Seborrheic skin lesions Glossostomatitis Distal sensitive polyneuropathy with burning of
Cobalamin deficiency (Vitamin B12).
Etiology. The main cause of this deficiency is the intrinsic factor deficiency of Biermer’s anemia. Digestive pathologies with malabsorptions are also responsible: Crohn’s disease with involvement of the terminal ileum, Wipple’s disease, a blind loop
Pantothenic acid deficiency
Extremely widespread in food. Pantothenic acid deficiency is very rare. It causes : Headaches, Sleep disorders, Distal sensory polyneuropathy.
Folic acid deficiency
There is an interdependence of folic acid and vitamin B12. Gives the same table as Vitamin B12 deficiency: Peripheral nerve damage Combined spinal sclerosis, Encephalopathy or psychiatric disorders, Ataxia, Optic nerve atrophy.
Neurological impairment of celiac disease
This disease causes chronic malabsorption linked to gluten intolerance. She can give: Peripheral sensory neuropathy Cerebellar or spinal ataxia (combined spinal sclerosis) Myositis.
Alcoholic and nutritional neuropathies ABONNE
Linked to a deficiency in essential nutrients. These neuropathies are frequent in developing countries, deficiencies being endemic. They mainly affect vitamin B deficiencies: B1 (beriberi), B6, B9 In developed countries, they are rather linked to