Tag: Peripheral neuropathy
Hereditary neuropathies due to hypersensitivity to pressure.
Epidemiology The true prevalence of hereditary pressure hypersensitivity neuropathy (HNPP) is unknown, as the disease is underdiagnosed, but is estimated to be between 1/50,000 and 1/20,000. Clinical description The disease usually occurs between the second
Hereditary neuropathies due to hypersensitivity to pressure.
Epidemiology The true prevalence of hereditary pressure hypersensitivity neuropathy (HNPP) is unknown, as the disease is underdiagnosed, but is estimated to be between 1/50,000 and 1/20,000. Clinical description The disease usually occurs between the second
Tomacular neuropathy
Or hereditary neuropathy with hypersensitivity to pressure (HNPP) Etiology The disease is caused by a mutation in the PMP22 (17p12) gene and other genes. PMP22 encodes peripheral myelin protein 22 (PMP22) which is expressed predominantly
Cervico-thoracic outlet syndrome
Anatomical reminder Cervico-thoracic parade syndrome corresponds to the compression of the brachial plexus (all of the upper limb nerves), the subclavian artery and/or the subclavian vein in the passage formed by the inter-scalènic parade and
Diabetic neuropathies. MEDECIN
Diabetic neuropathies. The frequency of diabetic neuropathy is more than 50% in patients with diabetes for more than 25 years. There are an estimated 100,000,000 patients with diabetic neuropathy worldwide. At the time of diagnosis
Canal syndromes
Root canal syndromes: definition Nerve compression syndromes, called “ductal syndromes” (entrapment neuropathy in the English) are defined as the clinical translation of a conflict between a peripheral nerve trunk and a particular anatomical region of
Meralgia paresthetica syndrome
Anatomical reminder Originates from the ventral branches of the 2nd and 3rd lumbar root It passes behind the psoas muscle (in red), exits the lateral part of the psoas towards its middle and crosses ventrally
Tarsal tunnel syndrome
Pathophysiology. Tarsal tunnel syndrome is a tunnel syndrome characterized by compression of the posterior tibial nerve and/or its distal terminal branches by the internal annular ligament. The posterior tibial nerve gives, in the retro-malleolar region,
Tarsal tunnel syndrome
Pathophysiology. Tarsal tunnel syndrome is a tunnel syndrome characterized by compression of the posterior tibial nerve and/or its distal terminal branches by the internal annular ligament. The posterior tibial nerve gives, in the retro-malleolar region,
Tarsal tunnel syndrome
Pathophysiology. Tarsal tunnel syndrome is a tunnel syndrome characterized by compression of the posterior tibial nerve and/or its distal terminal branches by the internal annular ligament. The posterior tibial nerve gives, in the retro-malleolar region,
Howship-Romberg syndrome
Anatomical reminder Corresponds to damage to the obturator nerve Born from roots L2-L3-L4 It first passes behind the psoas major, emerges from it via the medial edge and descends vertically into the pelvis from which
Meralgia paresthetica syndrome
Anatomical reminder Originates from the ventral branches of the 2nd and 3rd lumbar root It passes behind the psoas muscle (in red), exits the lateral part of the psoas towards its middle and crosses ventrally
Fibular nerve compression syndrome
Anatomical reminder The common peroneal nerve is formed by bifurcation of the sciatic nerve at the apex of the popliteal fossa. It runs along the medial edge of the biceps femoris muscle then its tendon.
Idiopathic radial palsy
Anatomical reminder From the posterior and lower part of the axillary fossa, it runs downwards and outwards into the posterior brachial region along the posterior surface of the humerus in the radial groove (in contact
Cervico-thoracic outlet syndrome
Anatomical reminder Cervico-thoracic parade syndrome corresponds to the compression of the brachial plexus (all of the upper limb nerves), the subclavian artery and/or the subclavian vein in the passage formed by the inter-scalènic parade and
Suprascapular nerve syndrome
Anatomical reminder The suprascapular nerve detaches from the upper primary trunk of the brachial plexus. It contains C5 C6 fibers. It passes through the coracoid notch (1) under the coracoid ligament (in green) then at
Ulnar canal syndrome at the elbow
Anatomical reminder 1- Radial nerve 2- vessels 3-Median nerve 4- Brachialis muscle 5- Humerus 6-Ulnar nerve 7- Olecranon The ulnar nerve travels in the epitrochleo-olecranon groove on the inner side of the elbow. It relates
Ulnar canal syndrome at the elbow
Anatomical reminder 1- Radial nerve 2- vessels 3-Median nerve 4- Brachialis muscle 5- Humerus 6-Ulnar nerve 7- Olecranon The ulnar nerve travels in the epitrochleo-olecranon groove on the inner side of the elbow. It relates
Fibular nerve compression syndrome
Anatomical reminder The common peroneal nerve is formed by bifurcation of the sciatic nerve at the apex of the popliteal fossa. It runs along the medial edge of the biceps femoris muscle then its tendon.
Canal syndromes
Root canal syndromes: definition Nerve compression syndromes, called “ductal syndromes” (entrapment neuropathy in the English) are defined as the clinical translation of a conflict between a peripheral nerve trunk and a particular anatomical region of
Carpal tunnel syndrome MEDECIN
Anatomical reminder Carpal tunnel syndrome is linked to compression of the median nerve in the wrist. The carpal tunnel is a narrow tunnel formed posteriorly by the carpal bones and anteriorly by the anterior annular
Carpal tunnel syndrome MEDECIN
Anatomical reminder Carpal tunnel syndrome is linked to compression of the median nerve in the wrist. The carpal tunnel is a narrow tunnel formed posteriorly by the carpal bones and anteriorly by the anterior annular
Anterior interosseous nerve syndrome
Anatomical reminder The interosseous nerve is the main branch of the median nerve in the forearm. It appears between 5 and 8 cm below the elbow at the level of the pronator teres muscle. He
Idiopathic radial palsy
Anatomical reminder From the posterior and lower part of the axillary fossa, it runs downwards and outwards into the posterior brachial region along the posterior surface of the humerus in the radial groove (in contact
Cervico-thoracic outlet syndrome
Anatomical reminder Cervico-thoracic parade syndrome corresponds to the compression of the brachial plexus (all of the upper limb nerves), the subclavian artery and/or the subclavian vein in the passage formed by the inter-scalènic parade and
Suprascapular nerve syndrome
Anatomical reminder The suprascapular nerve detaches from the upper primary trunk of the brachial plexus. It contains C5 C6 fibers. It passes through the coracoid notch (1) under the coracoid ligament (in green) then at
Guyon compartment syndrome
Anatomical reminder There is no synovium in Guyon’s canal where only the artery and the ulnar nerve pass. Consequently, any compression of the ulnar nerve in this compartment is of extrinsic origin. At the wrist,
Ulnar canal syndrome at the elbow
Anatomical reminder 1- Radial nerve 2- vessels 3-Median nerve 4- Brachialis muscle 5- Humerus 6-Ulnar nerve 7- Olecranon The ulnar nerve travels in the epitrochleo-olecranon groove on the inner side of the elbow. It relates
Carpal tunnel syndrome
Anatomical reminder Carpal tunnel syndrome is linked to compression of the median nerve in the wrist. The carpal tunnel is a narrow tunnel formed posteriorly by the carpal bones and anteriorly by the anterior annular
Canal syndromes
Root canal syndromes: definition Nerve compression syndromes, called “ductal syndromes” (entrapment neuropathy in the English) are defined as the clinical translation of a conflict between a peripheral nerve trunk and a particular anatomical region of
Hypoglycemic neuropathy MEDECIN
Etiology Two pathologies are likely to cause neuropathy (rare forms): Insulinoma (benign or malignant tumor secreting insulin), Insulin treatment responsible for repeated hypoglycaemia. Clinical Description It is a predominantly distal motor and sensory neuropathy (feet
Neuropathies and hyperlipidemia MEDECIN
Rare, it causes sensory impairment distally with a sensation of paresthesias at the tips of the feet. Treatment of hyperlipidemia results in recovery from neuropathy within a few months.
Neuropathies and hyperthyroidism MEDECIN
Description This complication is rare and presents in the form of sensory-motor impairment with predominance of sensitivity disorders. This damage is reversible with treatment of hyperthyroidism (minimum 6 months). Not to be confused with the
Relapsed forms of neuropathies MEDECIN
Etiology Hereditary neuropathies due to hypersensitivity to pressure. Chronic relapsing polyradiculoneuritis.
Acute forms of neuropathies MEDECIN
Installation in a few hours: Mainly vasculitis (polyarteritis nodosa) The picture is more of a multineuritis with multiple radicular or truncal involvement. Installation in a few days: – Guillain-Barrè syndrome and its variants. – Neuropathy
Chronic forms of neuropathies MEDECIN
Etiologies: Established over years, sometimes since childhood. Hereditary polyneuropathies. Chronic polyradiculoneuritis. Polyradiculopathies associated with monoclonal IgM gammopathy.
Subacute neuropathies MEDECIN
Etiology Installation in several months. In general : – Metabolic neuropathies, – neuropathies of deficiency origin, – toxic neuropathies, – alcoholic neuropathies, – dysproteinemia neuropathies (myeloma, plasmacytoma, cryoglobulemia, monoclonal gammopathy), – lymphoma neuropathies, – acquired
Toxic neuropathies MEDECIN
Below is a list of toxic agents used in industry and potentially toxic to peripheral nerves. This list is not exhaustive. – Acrylamide (flocculating agent) causes sensory damage to large nerves with sensory ataxia. –
Mucocutaneous signs associated with certain neuropathies MEDECIN
Ulcers and poor perforation: Found in diabetic neuropathy, hereditary sensory and dysautonomic neuropathies, and in neuropathy linked to leprosy. Purpura: Found in cryoglobulinemia and vasculitis. Mees lines: (definition) Seen in arsenic and thallium poisoning. Bullous
Diffuse Scarring Hyperesthesia Syndrome (DCHS)
This new clinical entity is found in some patients with chronic pain. Its current incidence is not known. It consists of a scarring neuropathy affecting all of the scars found in a patient. This entity
Ocular signs associated with peripheral neuropathy ABONNE
Corneal opacities: Found in Fabry disease, amyloid neuropathy and Tangier disease. Cataract: In Fabry disease and Refsum disease. Optic atrophy: Found in Refsum disease and Charcot-Marie-Tooth disease. Retinitis pigmentosa: Found in Refsum disease and Charcot-Marie-Tooth
Mucocutaneous signs associated with certain neuropathies ABONNE
Ulcers and poor perforation: Found in diabetic neuropathy, hereditary sensory and dysautonomic neuropathies, and in neuropathy linked to leprosy. Purpura: Found in cryoglobulinemia and vasculitis. Mees lines: (definition) Seen in arsenic and thallium poisoning. Bullous
Toxic neuropathies ABONNE
Below is a list of toxic agents used in industry and potentially toxic to peripheral nerves. This list is not exhaustive. – Acrylamide (flocculating agent) causes sensory damage to large nerves with sensory ataxia. –
Dejerine-Sottas syndrome
Hereditary sensorimotor disease type III or Dejerine-Sottas disease Onset in childhood, most often before the age of three. Causes muscular atrophy of the extremities which can spread towards the roots with sometimes children having to
Hereditary sensory neuropathies (HSN I and II)
Pathophysiology and clinical These two forms cause damage to spinal ganglion neurons. They cause sensitivity disorders without motor impairment. The pathology begins in childhood or before the age of 30. Form 1 is autosomal dominant
Tangier disease
Definition Very rare genetic neurometabolic disease characterized, biochemically, by an almost total absence of high density lipoproteins (HDL) in the plasma and, clinically, by enlargement of the liver, spleen, lymph nodes and tonsils, as well
Genetically determined neuropathies
Etiologies They are many : – Peroneal atrophy or Charcot-Marie-Tooth polyneuropathy (CMT). – Hereditary amyloid neuropathy. – Dejerine-Sottas disease. – Refsum disease. – Hereditary sensory neuropathies (HSN I and II). – Hereditary dysautonomic sensory neuropathies
Subacute neuropathies ABONNE
Etiology Installation in several months. In general : – Metabolic neuropathies, – neuropathies of deficiency origin, – toxic neuropathies, – alcoholic neuropathies, – dysproteinemia neuropathies (myeloma, plasmacytoma, cryoglobulemia, monoclonal gammopathy), – lymphoma neuropathies, – acquired
Chronic forms of neuropathies ABONNE
Etiologies: Established over years, sometimes since childhood. Hereditary polyneuropathies. Chronic polyradiculoneuritis. Polyradiculopathies associated with monoclonal IgM gammopathy.
Acute forms of neuropathies. ABONNE
Installation in a few hours: Mainly vasculitis (polyarteritis nodosa) The picture is more of a multineuritis with multiple radicular or truncal involvement. Installation in a few days: – Guillain-Barrè syndrome and its variants. – Neuropathy
Relapsed forms of neuropathies ABONNE
Etiology Hereditary neuropathies due to hypersensitivity to pressure. Chronic relapsing polyradiculoneuritis.
Neuropathies and hyperthyroidism ABONNE
Description This complication is rare and presents in the form of sensory-motor impairment with predominance of sensitivity disorders. This damage is reversible with treatment of hyperthyroidism (minimum 6 months). Not to be confused with the
Neuropathies and hyperlipidemia ABONNE
Rare, it causes sensory impairment distally with a sensation of paresthesias at the tips of the feet. Treatment of hyperlipidemia results in recovery from neuropathy within a few months.
Diabetic neuropathies
Diabetic neuropathies. The frequency of diabetic neuropathy is more than 50% in patients with diabetes for more than 25 years. There are an estimated 100,000,000 patients with diabetic neuropathy worldwide. At the time of diagnosis
Lyme disease
Causal agent: Due to a spirochete bacteria of the genus Borrelia. Three species of Borrelia are known to cause Lyme disease: Borrelia Burgdorferi, Borrelia Garinii, Borrelia Afzelii. Epidemiology : Lyme disease is transmitted by tick
Chagas disease or American trypanosomiasis
Described in 1909 by Carlos Chagas. Endemic tropical parasitic anthropozoonosis in 21 countries in Central and South America. 18 million people are estimated to be infected in Latin America. Between 2 to 3 million individuals
Brucellosis
Brucellosis or Malta fever, melitococcal disease. Causal agent: Three germs from the same family: Brucella melitensis, Brucella abortus bovis, Brucella abortus suis. Asporulate aerobic gram-negative coccobacillus. In France the number of human cases is decreasing,
Neuropathies of infectious origin
Neuropathies of infectious origin Three types of infectious agent can be directly or indirectly responsible for neuropathy: viruses, bacteria and parasites. Neuropathies of viral origin: Herpes virus infection Varicella zoster virus infection Cytomegalovirus (CMV) infection
Small fiber neuropathy
Due to damage to the small A delta and C fibers Definition : Small fiber neuropathies are neuropathies affecting small somatic fibers (sensation) and/or fibers of the autonomic nervous system. As a result, autonomic functions,
Hypoglycemic neuropathy ABONNE
Etiology Two pathologies are likely to cause neuropathy (rare forms): Insulinoma (benign or malignant tumor secreting insulin), Insulin treatment responsible for repeated hypoglycaemia. Clinical Description It is a predominantly distal motor and sensory neuropathy (feet